The Science Behind Biomed

LactoSpore® is Biomed’s bacteria of choice, and we want you to know exactly why we choose to use this particular Live Cultures preparation in our Daily Digestive Supplement.

LactoSpore® is a preparation containing the lactic acid forming microorganism (often called a “probiotic”) Bacillus coagulans MTCC 5856 or B. coagulans for short. Bacillus coagulans was originally known in literature as Lactobacillus sporogenes and both of these terms are still used in literature interchangeably.

How does LactoSpore® work?

The human digestive tract contains around 400 different bacterial species that reduce the growth of harmful bacteria and promote a healthy digestive system. Lactic acid producing bacteria are by far the largest inhabitant group amongst them all.

Given the pressures of a modern lifestyle, it can be a tricky task to maintain a normal, healthy and balanced microbial population in the digestive tract. In fact, most of us have a smaller variety of bacteria in our bodies than our great grandparents did.

From the foods we eat, to the medicines we take, and even increased stress levels our modern lifestyles mean that some of those good bacteria are being killed off.

Additional factors that might make this task even trickier are stress caused by sudden changes in food consumption patterns, exposure to environmental pollutants, extensive travel and unexpected changes in weather.

Therefore, under such adverse circumstances, the harmful bacteria may become predominant (a condition referred to as “bacterial overgrowth”) and create an imbalance or dysbiosis, which may in turn impair normal gut function and lead to various problems, ranging from inefficient digestion, diarrhoea, constipation and flatulence to severe gastro-intestinal disorders.

So what can we do to bring some of those health boosting bacteria back? A logical approach to restoring the balance of intestinal flora would be the use of naturally occurring microorganisms. A superior and potential species among Lactobacillus is Bacillus coagulans. This species forms spores, which on activation in the acidic environment of the stomach, can germinate and proliferate in the intestine, produce the favoured L (+) form of lactic acid and effectively prevent the growth of pathogens (harmful bacteria).

The beneficial activities of LactoSpore® in various conditions like gastro-intestinal disorders and Irritable Bowel Syndrome (IBS) may be attributed to

  • Stimulating the growth of other beneficial bacteria like Faecalibacterium prausnitzii in the gut. Establishing a healthy microflora eventually helps in reducing toxins as well as the growth of other bacteria / viral pathogens.
  • Eliminating acids, antibiotics and other substances that might compete for colonisation sites and nutrients (Keller et al., 2010).
  • Production of short-chain fatty acids (SCFAs) (Kasińska and Drzewoski, 2015).

How Does LactoSpore® Arrive, Survive & Thrive?

LactoSpore®  is a sporebiotic; it is this spore-forming nature of these bacteria that makes them resistant to most chemical and physical conditions (e.g. acid and heat) and therefore they are able to survive manufacturing, shipping and storage with no loss of viable count.

Bacillus spores are naturally designed to survive digestion. The reason for their inherent survivability comes from their bi-phasic life cycle. This means that the Bacillus spores can transition interchangeably from their dormant form to their active form, depending on the environment. In its dormant spore form, Bacillus will surround itself with an endospore, which is a tough, natural outer shell that protects it from light, heat, pressure, acid, lack of oxygen, and other environmental factors. This key feature is what allows the strain to survive easily through digestion without the need for enteric-coated capsules or refrigeration. Other non spore forming bacteria such as Lactobacillus cannot survive the acidic conditions of the gut and are therefore rendered virtually ineffective.

Once settled in the intestines, Bacillus coagulans is able to survive and flourish through the mechanism of competitive exclusion. There is first a competition for limited nutrients by all bacteria, the acidic environment created by the production of lactic acid by Bacillus coagulans prevents the growth of pathogenic microbes and allows growth of Bacillus coagulans which ultimately dominate the microbiota. In addition, Bacillus coagulans also produces Bacteriocins (antimicrobial proteinaceous compounds) that are inhibitory towards both Gram (+) and Gram (-) bacteria.

LactoSpore® is Clinically Evaluated and Accepted Across the Globe

Health Canada Approval & IBS Claim

In 2016, Health Canada, the federal department which regulates products that help people of Canada maintain and improve their health, issued the following approved health claim for LactoSpore®

“Helps relieve abdominal pain associated with IBS (Irritable Bowel Syndrome)”.

Accepted for Deposit in the Microbial Type Culture Collection and Gene Bank

LactoSpore® has also been accepted for deposit in the Microbial Type Culture Collection (MTCC) and Gene Bank. The microbial culture was accepted for deposit in MTCC-IDA, was assigned MTCC number 5856 and preserved in the patent collection of MTCC on 19th Sept, 2013.

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